1、NMN是什么？ NAD+是什么？ 辅酶Ⅰ是什么？
With the development and progress of our science, we have found a solution to anti-aging, namely NMN, which can effectively delay aging and keep healthy. Now let’s understand the cellular polyploid NMN of explosive fire. What are its functions?
1. What is NMN? What is NAD +? What is coenzyme I?
NMN is the abbreviation of nicotinamide mononucleotide, with molecular weight of 334.2192. It is an inherent substance in human body, and also rich in some fruits and vegetables. NMN is the precursor of NAD + in human body, and its function is reflected by NAD +.
What is NAD +? NAD + is also known as coenzyme I, full name nicotinamide adenine dinucleotide, also known as nicotinoside diphosphate. It exists in every cell and participates in thousands of reactions. NAD + is an important coenzyme in the tricarboxylic acid cycle, which promotes the metabolism of sugar, fat and amino acids, and participates in the synthesis of energy. NAD + is also the only substrate of coenzyme I consuming enzyme (the only substrate of DNA repair enzyme PARP, longevity protein sirtuins and cyclic ADP ribose synthase CD38 / 157).
What is coenzyme I? Coenzyme I (NAD +) is an indispensable coenzyme component of hundreds of enzyme proteins in human body, leading hundreds of life activities in human body. NMN (β – nicotinamide mononucleotide) is a direct precursor of coenzyme I and an important metabolic intermediate. NMN is synthesized by human body every day and then transformed into coenzyme I, which is very important for life activities.
2. Main effects of NAD + on human body
The tricarboxylic acid cycle is the final metabolic pathway of the three major nutrients (sugars, lipids and amino acids) in the human body, and it is also the hub of the metabolic relationship between sugars, lipids and amino acids. The tricarboxylic acid cycle provides more than 95% of the energy in the body, which is the energy hub of life.
3. Why not take NAD +?
Because the molecular weight of NAD + is twice that of NMN. Oral NAD + will be broken down, and although injection can enter the blood circulation, it still can’t directly pass through the cell membrane, can’t enter the cell interior, and can’t produce effect on the human body. So we can only take the precursor of NAD + to delay aging.
4. Does the human body have NAD +, need to be supplemented?
The human body has NAD +, but with the growth of age, the body produces less NAD +, while the body consumes more NAD +, which causes the content of NAD + in the body to gradually decrease. Scientific research has proved that the decline of NAD + can lead to aging and various diseases, and supplement of NAD + can delay aging and improve health. Therefore, NMN can be converted into NAD + in vivo to meet the anti-aging needs.
5. So many NAD + precursors, why eat NMN?
From the perspective of NAD + supplement, nicotinic acid, tryptophan, nicotinamide and NMN / NR are the four precursors that can supplement the three metabolic cycles of NAD +. Compared with other NAD + supplement methods, NMN bypasses the bottleneck of Nampt rate limiting enzyme and can rapidly supplement NAD + in vivo, which is the best and most scientific supplement method.
6. How can NMN be absorbed quickly?
The absorption of NMN in vivo is very rapid, which can rapidly increase the NAD + level in vivo
(1) Absorbed intact through the digestive system;
(2) 2-3 minutes into the blood;
(3) The content of NMN was increased in 15 minutes;
(4) The level of NAD + in blood, liver and other organs was increased rapidly;
7. Why can NMN increase NAD + level in tissues and organs?
NMN may be directly utilized by some target organs through microcirculation after being absorbed by intestinal epithelial villi. There is NMN transporter SLC12A8 in the intestine. SLC12A8 can directly transport NMN to cells with the help of sodium ions, and play a rapid role in the production of NAD +;
Some organs can directly use NMN to synthesize NAD +, such as intravenous injection of NMN can be directly absorbed by the kidney, liver directly absorbed a little; isotope tracing results confirmed that the cytoplasmic NMN can be used by mitochondria, and completely independent of the first decomposition into Nam and then synthesis of NAD +.
8. Can NMN replace medicine?
Mn is a dietary supplement and can’t replace medicine. We never claim or encourage you to replace any formal medical treatment with NMN. After NMN is transformed into NAD + in human body, it can activate longevity protein, repair DNA, promote cell energy production, regulate biological clock, improve sleep, enhance physique, and reduce blood sugar. All these are the conclusions of scientific research based on rigorous experiments.
9. NMN security
Some people may first question that NMN has so many and so good effects, but these are the results of animal experiments. There are still differences between animals and human bodies. Animals are effective, but human bodies may not be effective.
Firstly, the security of NMN is guaranteed
(1) It is the endogenous substance of the human body, which is everywhere in the body;
(2) It is the precursor of coenzyme NAD +, which plays a catalytic role in human body rather than a direct reactant;
(3) The recommended dose of NMN is safe: the recommended supplementary dose is 0.3-0.9g per day, which is far lower than the normal level in young people (5-7g), so it will not be excessive;
(4) The human clinical trials on NMN have passed the first phase of clinical trials (safety verification stage), and preliminarily proved the human safety;
(5) The manufacturing process is green and environment-friendly, without introducing any toxic and harmful substances with side effects.
10. Does NMN work for everyone?
“Effective” refers to the concept of drugs, and each drug has an “indication”. NMN is a food supplement, which is neither a drug nor a substitute for drugs. It is not appropriate to discuss “effective”. NMN is an endogenous coenzyme in human body. The content of NMN decreases with age. The supplement of exogenous NMN will participate in the catalytic reaction of human body. From the level of DNA repair to the level of “feeling the effect”, when physical fitness and age need to be different.