十问十答,NMN的真实效果怎么样?

十问十答,NMN的真实效果怎么样?

分类:NMN功效 时间:2021-03-30 作者:Folotto(中国)浏览量:52 次

随着我们科学的发展进步,已经找到了抗衰的破解之法,即NMN,它能有效地延缓衰老、保持身体健康。现在就来了解一下爆火的胞倍力NMN,究竟有哪些功效和作用呢?

1、NMN是什么? NAD+是什么? 辅酶Ⅰ是什么?

NMN是烟酰胺单核苷酸Nicotinamide mononucleotide的简称,分子量334.2192,它是人体内固有的物质,也富含在一些水果和蔬菜中。在人体中NMN是NAD+的前体,其功能是通过NAD+体现。

NAD+是什么?NAD+又叫辅酶Ⅰ,全称烟酰胺腺嘌呤二核苷酸,又称二磷酸烟苷,存在每一个细胞中参与上千项反应。NAD+是三羧酸循环的重要辅酶,促进糖、脂肪、氨基酸的代谢,参与能量的合成,NAD+又是辅酶I消耗酶的唯一底物(DNA修复酶PARP的唯一底物、长寿蛋白Sirtuins的唯一底物、环ADP核糖合成酶CD38/157的唯一底物)。

辅酶Ⅰ是什么?辅酶Ⅰ(NAD+)是人体中数百个酶蛋白不可或缺的辅酶成分,主导人体内数百项生命活动。NMN(β-烟酰胺单核苷酸)是辅酶Ⅰ直接前体物质,是一个重要的人体代谢中间产物。人体每天大量合成NMN,再转化为对于生命活动至关重要的辅酶I。

2、NAD+对人体的主要影响

三羧酸循环是人体三大营养(糖类、脂类、氨基酸)的最终代谢通路,也是糖类、脂类和氨基酸代谢联系的枢纽,三羧酸循环在体内提供了超过95%的能量,是生命体的能量枢纽。

3、为什么不直接服用NAD+?

因为NAD+分子量大,是NMN的两倍。口服的NAD+会被分解掉,而注射虽然可以进入血液循环,但还是无法直接穿过细胞膜,无法进入细胞内部,也就不能对人体产生效果。所以只能通过服用NAD+的前体来延缓衰老。

4、人体自身有NAD+,还需要另外补充吗?

人体内自身有NAD+,但是随着年龄的增长,身体产生的NAD+减少,而身体消耗的NAD+变多,引起体内NAD+的含量逐渐下降。科学研究已经证明NAD+的下降会导致衰老和各种随之而来的疾病,而补充NAD+可延缓衰老,改善健康。所以通过服用NMN,在体内转化成NAD+,可以满足抗衰老需求。

5、NAD+前体那么多,为什么吃NMN?

从补充NAD+的角度来讲,可以补充NAD+三个代谢循环的四类前体有烟酸、色氨酸、烟酰胺和NMN/NR。而相较NAD+的其他补充方式, NMN则绕过了NAMPT限速酶的瓶颈,可以迅速补充体内NAD+,是最佳及最科学的补充方法。

6、NMN如何快速被吸收?

NMN在体内的吸收非常迅速,可以迅速提高体内NAD+水平:

(1)通过消化系统完好无损地吸收;

(2)2~3分钟进入血液;

(3)15分钟内提升组织中的NMN含量;

(4)迅速提升血液、肝脏等器官中的NAD+水平;

十问十答,NMN的真实效果怎么样?插图
7、NMN为何能提高组织器官中NAD+水平?

NMN被小肠上皮绒毛吸收后,可能通过微循环直接被某些靶器官利用。肠道内存在NMN的转运蛋白Slc12a8,Slc12a8蛋白会在钠离子的帮助下将NMN直接运输到细胞中,并迅速发挥作用,用于NAD+的生产;

有些脏器能够直接利用NMN合成NAD+,例如静脉注射NMN能被肾脏直接吸收,肝脏直接吸收少许;同位素示踪结果证实:胞浆的NMN能够被线粒体利用,且完全不依赖于先分解成NAM再合成NAD+。

8、NMN能代替药吗?

MN属于膳食补充剂,不能代替药物。我们也从不宣称或是鼓励大家用NMN取代任何正规医学治疗。NMN在人体内转化为NAD+之后,起到激活长寿蛋白、修复DNA、促进细胞能量产生、调节生物钟、改善睡眠、增强体质、降低血糖等作用,这些都是以严谨实验为基础的科学研究得到的结论。

9、NMN安全性

有些人可能首先会质疑,NMN的功效这么多这么好,可这些都是动物实验的结果,从动物到人体还是有区别的,动物有效人体可未必有效。

首先,NMN的安全性是有保障的,表现在:

(1)它是人体的内源性物质,身体中无处不在,无时不有;

(2)它是辅酶NAD+的前体,而辅酶NAD+在人体中起催化反应进行的作用,而不是直接的反应物;

(3)NMN的推荐剂量安全:建议补充的剂量为每日0.3-0.9克,远比年轻人体内正常水平(5-7克)低,所以不会过量;

(4)关于NMN的人体临床实验均已通过一期临床(安全性验证阶段),初步证明了人体安全性;

(5)制造工艺绿色环保,无引入任何有毒有害、有副作用的物质。

10、NMN是否对所有人都有效?

“有效”是针对药物的概念,每个药物都有一个“适应症”,而NMN是食物补充剂,其不是药物也不能代替药物,讨论“是否有效”并不适合。NMN是人体内源的辅酶,含量随着年龄降低,补充外源的NMN都会参与人体的催化反应。从DNA修复层面到能“感受到效果”的层面,体质和年龄不同需要的时。

With the development and progress of our science, we have found a solution to anti-aging, namely NMN, which can effectively delay aging and keep healthy. Now let’s understand the cellular polyploid NMN of explosive fire. What are its functions?

1. What is NMN? What is NAD +? What is coenzyme I?

NMN is the abbreviation of nicotinamide mononucleotide, with molecular weight of 334.2192. It is an inherent substance in human body, and also rich in some fruits and vegetables. NMN is the precursor of NAD + in human body, and its function is reflected by NAD +.

What is NAD +? NAD + is also known as coenzyme I, full name nicotinamide adenine dinucleotide, also known as nicotinoside diphosphate. It exists in every cell and participates in thousands of reactions. NAD + is an important coenzyme in the tricarboxylic acid cycle, which promotes the metabolism of sugar, fat and amino acids, and participates in the synthesis of energy. NAD + is also the only substrate of coenzyme I consuming enzyme (the only substrate of DNA repair enzyme PARP, longevity protein sirtuins and cyclic ADP ribose synthase CD38 / 157).

What is coenzyme I? Coenzyme I (NAD +) is an indispensable coenzyme component of hundreds of enzyme proteins in human body, leading hundreds of life activities in human body. NMN (β – nicotinamide mononucleotide) is a direct precursor of coenzyme I and an important metabolic intermediate. NMN is synthesized by human body every day and then transformed into coenzyme I, which is very important for life activities.

2. Main effects of NAD + on human body

The tricarboxylic acid cycle is the final metabolic pathway of the three major nutrients (sugars, lipids and amino acids) in the human body, and it is also the hub of the metabolic relationship between sugars, lipids and amino acids. The tricarboxylic acid cycle provides more than 95% of the energy in the body, which is the energy hub of life.

3. Why not take NAD +?

Because the molecular weight of NAD + is twice that of NMN. Oral NAD + will be broken down, and although injection can enter the blood circulation, it still can’t directly pass through the cell membrane, can’t enter the cell interior, and can’t produce effect on the human body. So we can only take the precursor of NAD + to delay aging.

4. Does the human body have NAD +, need to be supplemented?

The human body has NAD +, but with the growth of age, the body produces less NAD +, while the body consumes more NAD +, which causes the content of NAD + in the body to gradually decrease. Scientific research has proved that the decline of NAD + can lead to aging and various diseases, and supplement of NAD + can delay aging and improve health. Therefore, NMN can be converted into NAD + in vivo to meet the anti-aging needs.

5. So many NAD + precursors, why eat NMN?

From the perspective of NAD + supplement, nicotinic acid, tryptophan, nicotinamide and NMN / NR are the four precursors that can supplement the three metabolic cycles of NAD +. Compared with other NAD + supplement methods, NMN bypasses the bottleneck of Nampt rate limiting enzyme and can rapidly supplement NAD + in vivo, which is the best and most scientific supplement method.

6. How can NMN be absorbed quickly?

The absorption of NMN in vivo is very rapid, which can rapidly increase the NAD + level in vivo

(1) Absorbed intact through the digestive system;

(2) 2-3 minutes into the blood;

(3) The content of NMN was increased in 15 minutes;

(4) The level of NAD + in blood, liver and other organs was increased rapidly;

7. Why can NMN increase NAD + level in tissues and organs?

NMN may be directly utilized by some target organs through microcirculation after being absorbed by intestinal epithelial villi. There is NMN transporter SLC12A8 in the intestine. SLC12A8 can directly transport NMN to cells with the help of sodium ions, and play a rapid role in the production of NAD +;

Some organs can directly use NMN to synthesize NAD +, such as intravenous injection of NMN can be directly absorbed by the kidney, liver directly absorbed a little; isotope tracing results confirmed that the cytoplasmic NMN can be used by mitochondria, and completely independent of the first decomposition into Nam and then synthesis of NAD +.

8. Can NMN replace medicine?

Mn is a dietary supplement and can’t replace medicine. We never claim or encourage you to replace any formal medical treatment with NMN. After NMN is transformed into NAD + in human body, it can activate longevity protein, repair DNA, promote cell energy production, regulate biological clock, improve sleep, enhance physique, and reduce blood sugar. All these are the conclusions of scientific research based on rigorous experiments.

9. NMN security

Some people may first question that NMN has so many and so good effects, but these are the results of animal experiments. There are still differences between animals and human bodies. Animals are effective, but human bodies may not be effective.

Firstly, the security of NMN is guaranteed

(1) It is the endogenous substance of the human body, which is everywhere in the body;

(2) It is the precursor of coenzyme NAD +, which plays a catalytic role in human body rather than a direct reactant;

(3) The recommended dose of NMN is safe: the recommended supplementary dose is 0.3-0.9g per day, which is far lower than the normal level in young people (5-7g), so it will not be excessive;

(4) The human clinical trials on NMN have passed the first phase of clinical trials (safety verification stage), and preliminarily proved the human safety;

(5) The manufacturing process is green and environment-friendly, without introducing any toxic and harmful substances with side effects.

10. Does NMN work for everyone?

“Effective” refers to the concept of drugs, and each drug has an “indication”. NMN is a food supplement, which is neither a drug nor a substitute for drugs. It is not appropriate to discuss “effective”. NMN is an endogenous coenzyme in human body. The content of NMN decreases with age. The supplement of exogenous NMN will participate in the catalytic reaction of human body. From the level of DNA repair to the level of “feeling the effect”, when physical fitness and age need to be different.

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